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Evidence suggests that patients with CKD are prone to increased incidence of ischemic strokes, with cognitive dysfunction, dementia, transient infarcts, and white matter lesions widespread in mild to moderate CKD patients (Chelluboina and Vemuganti, 2019)

The brain also influences kidney function through several key pathways, primarily involving neural, metabolic, and hemodynamic mechanisms, including the SNS, RAAS, HPA axis, and neural circuits and associated feedback loops (Freeman and Wadei, 2015

An anti-hypertrophic role of FOXO3 in the heart was also shown 67

Polyphenols: Natural compounds with promising potential in treating polycystic ovary syndrome