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~5% of APAP is metabolized via oxidation by the hepatic cytochrome P450 (mainly CYP2E1) into a toxic, highly reactive intermediate metabolite N-acetyl-p-benzoquinoneimine (NAPQI) *

May 23 2021 Pellegrini et al., Gastroenterology, doi:10.1016/S0016-5085(21)02756-6 A Retrospective Analysis of Outcomes Amongst COVID-19 Infected Patients with Acute Hepatitis Receiving N-Acetylcysteine Therapy in a Safety Net Hospital 52% lower mortality (p=0.0001)

Some metabolic pathways were only mediated by one CYP isoform, such as the S -demethylation of 4MeS-NE-BP and 4MeS-P-BP via CYP2D6

doi: 10.1016/j.freeradbiomed.2012.05.029