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Josh Clemente: So essentially, it's an overdoing-it issue

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CrossRef The association between sarcopenia and carotid artery plaque: a mediation analysis of inflammatory biomarkers Hongze Lin, Shuling Liu, Jushun Zhang, Wenying Zhong, Mei Tu, Wen Wei BMC Endocrine Disorders.2026;[Epub] CrossRef Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) therapy decreases lean body mass and appendicular skeletal muscle mass index even until one year after the final treatment in patients with B-cell non-Hodgkin lymphoma Sanshiro Nakao, Daiji Ngayama, Chiaki Nakaseko, Naomi Shimizu Journal of Chemotherapy.2025

Patients suffering from AKI bear a heightened risk of disease progression to CKD followed by end-stage renal disease (ESRD), which is the final common clinical feature of renal failure [9]