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Symptoms of B12 Deficiency The symptoms of vitamin B12 deficiency include a mixture of the physical symptoms associated with peripheral neuropathy, as well as cognitive issues: Physical Symptoms Peripheral Neuropathy experiencing unpleasant sensations in the extremities (the hands, arms, legs and feet) due to nerve damage, such as those listed above Despite feeling the minor irritating phenomenon of pins and needles, persistently feeling the sensation may suggest that you have nerve damage, which should be taken seriously Issues with your eyesight, such as visual disturbances or impairments Experiencing paralysis in areas such as the extremities can suggest that nerve damage has become severe, so medical intervention should be sought as soon as possible

These changes in skin color can develop when a persons body is unable to produce enough RBCs

This result is likely due to the other Novosphingobium factor(s) that can induce the Eu mouth form as indicated in the experiments using the Novosphingobium vitamin B12-deficient diet (Fig