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Nat Commun 10:4731

406,407 Interestingly, IDH1 mutants compete for NADPH to synthesize 2-HG with other pathways that are critical for cell viability, resulting in further disruption of cellular metabolism and redox homeostasis in tumorigenesis

Weeks 17 and beyond (maintenance at 2.4 mg) Side effects typically reach their mildest point once a stable maintenance dose is established

Also, in vivo studies demonstrated the 30% increased wound healing ability of nanozyme compared to control-based ointment and commercial nitrofurazone ointment, respectively [178]