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Conversely, Abdullah & Singh 69 highlighted in their study about the cardiotoxicity and cardiovascular system-related effects of kratom, which included tachycardia, hypertension, coronary atherosclerosis, myocardial infarction, hypertensive cardiovascular disease, left ventricular hypertrophy, cardiac arrhythmia, cardiomegaly, cardiomyopathy, focal band necrosis in the myocardium, and myocarditis