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Clearance of blood urea in turn requires an osmotic gradient during its renal excretion, thus causing diuresis [114, 115]

The FIBA score for a protein is calculated based on this logic and is defined as the difference between the model age gaps original association with a trait and the association with that trait after randomization of a single feature

A phase II nonrandomized trial evaluating mirtazapine, a tetracyclic antidepressant, administered for 8 weeks to cancer patients without depression, reported that mirtazapine-treated patients gained weight and had an improved appetite.[43] In an exploratory study, olanzapine treatment of cancer patients with cachexia who were receiving active chemotherapy showed a nonsignificant trend toward improved weight.[44] Olanzapine has also been used in combination with megestrol acetate in advanced cancer, with results suggesting benefit.[45] It may be useful for patients on chemotherapy who have difficult-to-control nausea and weight loss