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Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses

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This mini review summarizes neurotrophin biology relevant to bone sarcoma, delineates mechanisms by which these pathways reprogram immune and stromal compartments, and evaluates therapeutic strategies ranging from ligand/receptor blockade to clinically available TRK inhibitors, with the objective of defining tractable approaches to restore immune competence in this disease

Some commenters suggested that CMS use an alternative term to refer to these technologies, such as Software as a Medical Device in conformance with FDA definitions, or clinical decision support tools. Some commenters provided suggestions on how CMS should categorize these types of services in terms of payment