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Consequently, pharmacological ROS scavenging diminishes Treg suppressive function, whereas Teffs recover function upon ROS inhibition [167]

found that the abnormal accumulation of double-stranded DNA in the cytoplasm may bind to the cytoplasmic DNA sensor (cGAS), thereby specifically triggering the STING-interferon (IFN) signaling pathway in microglia, promoting the expression and secretion of inflammatory cytokines