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Methylfolate speeds up methylation and neurotransmitter production. If this happens: reduce the dose or stop temporarily, try niacin (50100 mg) to use up excess methyl groups, switch to folinic acid, switch methylcobalamin to hydroxocobalamin, and ensure adequate potassium, magnesium, and glutathione. Whats wrong with folic acid

While the chemical intermediates of DA oxidation are thoroughly described elsewhere [61], it should be noted that DA quinones have been implicated in mitochondrial dysfunction by forming adducts with proteins such as the subunit of ATP synthase [63] and the E3 ubiquitin ligase Parkin [64], inducing mitochondrial permeability transition [63,65], and inhibiting complex I [66]