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The presence of neurological complications substantially affects response time

August 2008

Users should not expect the appetite reduction that comes with compounds like semaglutide or tirzepatide

However, tesofensine faces significant challenges - cardiovascular side effects (increased heart rate and blood pressure) raised safety concerns, FDA has not approved it despite promising efficacy data, development stalled after Phase 3 trials, currently available only through research chemical suppliers with questionable legality, and the stimulant-like mechanism creates dependency and tolerance risks not seen with GLP-1 agonists