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Because it depletes hepatic glutathione levels and can cause irreversible liver damage

doi: 10.1007/s00726-011-0874-6

Another study developed phasetransitional Pt (IV) NPcRGD nanoparticles with a hybrid lipidpolymer shell for ovarian cancer, which are both GSHsensitive and ultrasoundresponsive, demonstrating enhanced therapeutic efficacy and reduced side effects in in vivo models [121]