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The chronic unpredictable stress model was also associated with similar neurobehavioural changes[55]

Essentially, we don't want phase 1 to be too fast (and create excess acetaldehyde), but we do want phase 2 to work efficiently and as fast as possible (to effectively remove acetaldehyde)

Research using cell culture models such as Calu-3 airway epithelial cells, has demonstrated that these cytokines affect the integrity and permeability of pulmonary epithelial barrier integrity by regulating key TJs proteins like occludin, claudin-2, and ZO-1