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Targeting the human gut microbiome with small-molecule inhibitors

2019;14 doi: 10.1002/biot.201800555

This can ultimately result in cell death, either through apoptosis or necrosis, depending on the severity of mitochondrial dysfunction and ATP loss (Supinski et al., 2020

In the clinical setting, 2-DG has thus far been evaluated only in early-phase trials focused on safety and dose escalation, either as monotherapy or in combination with chemotherapy or radiotherapy, including NCT00096707/NCT00196707, NCT00633087, and related studies, which enrolled patients with various advanced solid tumors or high-grade gliomas