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Oxidative stress in aging Aging is defined as an intrinsic, multifactorial, and progressive process characterized by tissue degeneration and progressive loss of organ function, ultimately leading to increased mortality (Liguori et al., 2018

While the study reported positive effects on cerebrospinal fluid biomarkers of neuroinflammation and neurodegeneration, it did not meet its primary clinical efficacy endpoint, highlighting the difficulty of translating biological signals into measurable clinical benefits in a heterogeneous patient population (65)

Using advanced Korean technology, the often difficult-to-process glutathione is encapsulated in phospholipid capsules that mimic the structure of the skin, ensuring maximum absorption and effectiveness

Importantly, this effect was reversed when cells were cultured with supernatant from chelator-treated macrophages [64]