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The rationale was that direct delivery to the joint would maximize local efficacy while minimizing systemic exposure

An NNMT Inhibitor Increases Strength and Alleviates the Need for Muscle Recovery To test the effects of 5-amino-1MQ, the Texas-based research group divided aged mice into four groups: one sedentary group with low activity, another sedentary group given the compound, a group that underwent rigorous exercise without treatment, and another that underwent exercise and treatment