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Molecular pathways in colorectal cancer

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has shown that glycine regulates the levels of S-adenosylmethionine (a direct methyl donor), which promotes the methylation of the GPX4 promoter, thereby enhancing the ferroptosis of RA-FLS ( Galectin-1 derived peptide 3 (G1dP3), a bioactive peptide derived from the galectin-1 structural domain, has potent anti-inflammatory effects on RA-FLS ( Besides these ferroptosis inducers, a recent study has demonstrated that icariin inhibits ferroptosis by activating the Xc-/GPX4 axis, thereby protecting RA-FLS from LPS-induced cell death

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