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Hyper-stimulation of low-grade inflammatory mediators triggers peripheral endotoxemia and a persistent inflammatory state, popularly called inflammaging (reviewed in Mechanistic Insight Into Gut Microbiome-Mediated Neurodegeneration A clear pathophysiological link between immune and metabolic dysregulation and neurodegenerative disorders in the brain had been previously established (reviewed in Yan et al., 2020)

Conclusion Our results provide evidence that GHK-Cu pretreatment is protective against CS-induced emphysema due to its anti-inflammatory and antioxidative effects

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As the main antioxidant enzyme in plasma, GPx3 is the only extracellular enzyme in the GPx family that reduces ROS products during normal metabolism or oxidative damage [15]