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Using the same assay we also observed a small fraction (0.5%) of non-disjunction events (MI NDJ), that is nonetheless significantly more than the zero NDJ events observed in the wild-type MER3 strains, and far smaller than in the mer3 strain (20%) (Fig

Sci., 2022, 9, 2106049 CrossRef CAS PubMed

doi: 10.1021/acsami.3c10562 153

Taken together, these findings emphasize that target selection is ultimately a systems-level decision, where integrating molecular evidence, disease-class specificity, expression context, and historical maturity provides a more robust framework than relying on any single metric alone