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In the skin and blood, the area under the curve (AUC) for SH-MN was 1.43 and 1.63 times that of SH-G, respectively, indicating that microneedles enhanced SINs transdermal penetration and increased its bioavailability (175)

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The FDA also state that exceeding the levels of exposure for mercury that would provide protection established by the ATSDR and EPA does not necessarily mean that any adverse effects will occur

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