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Meanwhile, elevated ROS activates pro-metastatic signaling pathways such as NF-B [263], promoting angiogenesis, extracellular matrix remodeling, inflammatory responses [318, 319], and epithelialmesenchymal transition (EMT) through upregulation of Snail and Twist [320]

Qian et al., 2015)

Median time between 1 st LSM reading from PSC diagnosis date was 3.3 years

Eligible studies specifically investigated the application of ctDCS for pain modulation, either in individuals with clinical pain or in healthy participants undergoing experimental pain induction