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Consequently, we observed that this beneficial effect, after direct injury (permanent ligation) applied to one or two major vessels, could instantly oppose more general damage (maintained intra-abdominal hypertension, either high (grade III) or very high (grade IV)), as all blood vessels which can be compressed with increased intra-abdominal pressure

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there are little data on the safety of continued use of these agents in patients who develop an infection while on therapy, although anecdotal evidence suggests that they can safely be restarted in many cases after the infection has resolved