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In addition, the increase in proinflammatory cytokines leads to the formation of fibrin amyloid microclot resistant to fibrinolysis, either by increased production of serum amyloid A (SAA) or by the release of -amyloid (A) peptide by platelets, resulting in capillary obstruction (156159)

Antioxidant Properties: Glutathione is a powerful antioxidant that protects cells from oxidative stress and damage caused by free radicals

They also thank Sheng WANG from State Key Laboratory of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, for technical assistance

Statins inhibit Rac1 activity to reduce superoxide production and were shown to be protective against AF in preclinical models [Figure 2] [72,73]