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Full text in Research Archive Olsbu, Inger Kirstine

These factors trigger the upregulation of adhesion molecules ICAM-1 and VCAM-1 through NF-B-mediated inflammatory pathways, facilitating the migration of immune cells into the vessel walls and promoting foam cell formation and plaque development

The death domain-related proteins RPK1, RPK3, and Fas on this necrosome directly phosphorylate the kinase domain-like protein (MLKL) to induce necroptosis