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If this mutation takes place in critical region of an oncogene or tumor suppressor gene, it can lead to cancer

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The role of the glutathione pathway in cellular defense against oxidative stress, particularly in environments compromised by surgical trauma and ischemia, has been substantiated through the upregulation of key enzymes such as GCLC, GPXs, GSR, and GSTs during the early phases of graft healing 14

389 CYP2J2 and CYP2C9 expression has also been correlated to high Ki-67 labeling indices in adenocarcinoma (EAC) and squamous cell carcinoma (ESCC)