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Genetic mutations can result in short telomeres and the development of the associated short telomere syndromes (pulmonary fibrosis and dyskeratosis congenita)

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Kuwabara et al., 2018 treated bronchoalveolar (BAL) tissue of Goto-Kakizaki (GK) and High Fat Diet (HFD) mouse with LPS and demonstrated an impaired in the chemotactic property of neutrophils, decrease in the neutrophil count, reduced release of IL-1, IL-6, TNF- and MPO activity along with an increase in CXCL3 levels