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167 Evasion of apoptosis brought about by H 2 S has been attributed mostly to CSE-generated H 2 S mediating the per-sulphidation of key proteins in different signalling pathways: nuclear factor-B (NF-B) in hepatoma cells, 168 the Keap1-transcriptional regulator of NRF2, 169 and the extracellular-signal-regulated kinase (ERK)-activating protein kinase 1

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Res (Washington D C) 9:1078 Xue J, Suarez JS, Minaai M, Li S, Gaudino G, Pass HI, Carbone M, Yang H (2021) HMGB1 as a therapeutic target in disease

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The existence of such a reservoir provides a plausible mechanism for how oxidative metabolism could proceed briskly in the parenchyma without being immediately reflected in vascular oxygen measurements (Schurr, 2025)

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