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In summary, the roGFP2 oxidation kinetics of PfGrx fusion constructs reflect at up to micromolar GSSG concentrations the glutathionylation kinetics of the glutaredoxin moiety in accordance with previous intracellular structure-function analyses and data interpretations 15,34,35

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Conditional knockout studies further indicate opposing roles for myeloid HIF-1 and HIF-2 in DSS colitis, where HIF-1 deficiency ameliorates inflammation but HIF-2 deficiency worsens disease (78)