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Peyton KJ, et al

(2018) found that the ERc-SrcHER2 complex plays a vital role in tamoxifen resistance, while c-Cbl reverses tamoxifen resistance by inhibiting the formation of the ERc-SrcHER2 complex

The existence of other IGF binding proteins, six in total, became clear when Hossenloop (20) developed Western ligand blotting as a technique to quantify these proteins