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Studies with GPx1 knockout mice revealed an important role of this enzyme in cardiac dysfunction (Lubos et al

Dieser Zusammenhang ist fr die Bezeichnung Master-Antioxidans verantwortlich: Glutathion kann durch Recycling Antioxidantien reaktivieren, die der Krper sonst ber die Nahrung aufnehmen und verstoffwechseln muss

In contrast, an overdose of APAP causes hepatotoxicity by saturating the sulfation pathway and generating NAPQI that leads to a robust reaction between NAPQI and hepatic glutathione stores, which subsequently depletes glutathione (Xie et al., 2015)

A series of mutants impaired in other genes putatively involved in glutathione homeostasis were however not more susceptible than WT