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The formation of heterodimers, more commonly named hybrid receptors, between type A or B isoforms of the insulin receptors (INSR A or INSR B ) and the IGF1R of which IR A -IGF1R are highly expressed in the fetus (and in malignant cells) and activated by IGF-II, may further point to the importance of IGF-II during the fetal period

These approaches are clinically proven, safe, and carry no legal or contamination risks

Because of that, the NICE recommendations lean towards individualised care: tailoring the dose, frequency and delivery method, following people up at around three months, and reviewing sooner if symptoms are severe or if someone is pregnant or breastfeeding