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As an example, Agrawal et al ., performed in silico studies by machine learning techniques based on AFP and non-AFP sequences revealing a higher frequency of certain residues (C, G, H, K, R, and Y) and the prevalence of R, V, K at N-terminus and C and H at the C-terminus of peptides (Agrawal et al., Table 2 Examples of semisynthetic and synthetic AFPs with clinical applications

Similar integrative strategies may be applicable in chronic inflammatory gynecologic conditions, where curcumin could contribute to long-term disease modulation with a favorable safety profile