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Weight reduction: Clinical trials report substantial bodyweight loss (up to ~11 kg more than GLP1 RA comparators over 26 weeks at higher doses) [3] [4]

[1] [2] The clinical trials that supported FDA approval did not identify muscle cramps or leg cramps as occurring at a significantly higher rate in semaglutide-treated patients compared to placebo groups

Comment: Several commenters suggested that CMS modify the policy to reduce or remove the requirement that at least 20 percent of ACOs' assigned beneficiaries must be enrolled in LIS or dually eligible in order for the ACO to be eligible for the HEBA