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Because the changes in H upon these mutations are unfavorable for folding, the observed improvements in stability were caused by entropic effects due to the release of water at the charged residues that we introduced (electrostatic solvation)

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The results showed that the fluorescence intensity at the tumor site gradually increased over time, reaching a peak at 6 h and maintaining a relatively high intensity for the subsequent 42 h, indicating the rapid and prolonged accumulation of nanoparticles at the tumor site (Fig

Physical and hematological: chronic, unexplained fatigue