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Moreover, it is noteworthy that nanotechnology offers immense potential in preventing and alleviating PIPN via two main strategies: 1) enhancing the targeting accumulation and/or activity of Pt drugs at tumor tissues while decreasing the off-target effects and 2) specific delivery of antioxidant agents toward the peripheral nervous system

Critically, in vitro binding or degradation does not guarantee efficacy in vivo due to the complex gastrointestinal environment, including variable pH, proteolytic enzymes, bile salts, and competition from resident microbiota (30, 94)

In rodents, adrenocortical cells obtain extracellular cholesterol mainly through the import of High Density Lipoprotein particles from the circulation 50

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