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With no lysine kinase 1 promotes metabolic derangements and RV dysfunction in pulmonary arterial hypertension

Second, the elevation of pentose phosphate pathway genes, including G6PD and 6-phosphogluconate dehydrogenase, facilitates purine biosynthesis and NAD(P)H generation, resulting in enhanced cell proliferation 37

Based on the findings that wild-type (WT) p53 represses SLC7A11 expression and p53 deficiency promotes SLC7A11 expression in cancer cells (Jiang et al., 2015), one would expect that p53 mutants with oncogenic functions, similar to p53 deficiency, should promote SLC7A11 expression