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10.1093/brain/awy132 Brain 121 HanA

Within the pathological milieu of uremia-associated CKD, the intestinal microbiome undergoes profound compositional dysregulation, manifesting as precipitous depletion of beneficial microbial taxaparticularly short-chain fatty acid (SCFA)-producing genera including Faecalibacterium prausnitzii , Roseburia, Bifidobacterium, and Lactobacillusconcomitant with the aberrant proliferation of opportunistic pathogenic species such as Escherichia coli , Shigella, and Enterococcus (Lyu et al., 2023

At most, youll feel a slight pinch as we insert the needle

Inflammatory responses increase oxidative stress and oxygen free radicals, which impair GAG synthesis