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(48) reported that daily administration of 50 mg/kg curcumin (intraperitoneal) effectively prevented PD-like symptoms induced by rotenone in mice, likely due to its inhibition of microglial NF-B-NLRP3 inflammasome activation and reduction of pro-inflammatory cytokines such as IL-1 and IL-18

FIGURE 3 The immunopharmacological effects of GSH are evident through several distinct but interconnected pathways, including regulation of inflammatory signaling networks like MAPK and NF-B, buffering of pathologic ROS as well as maintenance of cellular ROS signaling, and modulation of both peripheral and central immune cell activity (Bae et al., 2011

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