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Obesity and ageing: two sides of the same coin

Also, a phase III randomized placebo-controlled trial demonstrated that another compound protective against oxidative stress, dexpramipexole, did not improve motor function in ALS patients (Cudkowicz et al., 2013)

Given that synapses degrade and protective mechanisms fade as a function of normal ageing, it might be expected that synaptic dysfunction and loss is more pronounced in LLD [242, 243]