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The observed plasma increase in adenosine could be due to a decrease in adenosine deaminase activity, inhibition of adenosine kinase, or an increase in 5-nucleotidase, all of which can occur in the presence of oxidative stress [7072]

As ascorbate is soluble in water, its transfer through lipid plasma membrane is hampered

Exogenously administered agents in the form of a pill containing estrogen/progestin flood the bloodstream to acts upon the female genital tract and more importantly the brain to interrupt the normal hormonal feedback loop that exists between the brain and gonads

For urgent situations, expedited appeals must be decided within 72 hours