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Meta-analyses show that supplementation is a safe and effective way to increase muscle creatine concentrations, promoting the associated benefits

n = 8 and 7 samples from worms treated with control and prx-5 RNAi, respectively

doi:10.1016/j.ejphar.2015.03.011 Rossini M, Di Munno O, Valentini G, Bianchi G, Biasi G, Cacace E, Malesci D, La Montagna G, Viapiana O, Adami S (2007) Double-blind, multicenter trial comparing acetyl l-carnitine with placebo in the treatment of fibromyalgia patients