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Increases in the expression of various molecules that have been noted in reactive astrocytes across multiple contexts include GFAP, vimentin, nestin (probably labelling proliferating astrocytes), synemin plectin, -crystallin B chain, monoaminoxodase-B (MAO-B), heat shock factor binding protein 1, complement C3, lipocalin 2, C-X-C motif chemokine ligand 10, SerpinA3N, LCN2 and others, 20,95,96,97,98,99,100,101,102,103 but it important to note that no single molecular marker (including GFAP) is an absolute, required and sufficient, indicator of astrocyte reactivity, and no molecular markers have yet been identified that reliably distinguish amongst different reactive astrocyte phenotypes

Vitamin B6 and B12, together with folate, are also essential for DNA synthesis

NAC is a precursor to cysteine, the sulfur-containing amino acid required to synthesize glutathione, the primary intracellular antioxidant and detoxification cofactor in hepatocytes, renal tubular cells, and many immune cells

Tuch, D