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Studies have shown a direct correlation between glutathione levels and cancer proliferation and metastatic activity

GPX4 is an antioxidant enzyme that primarily reduces lipid peroxides, especially lipid hydroperoxides, into their corresponding alcohols, thus protecting cell membranes from oxidative damage [39]

Based on our previously reported genetic data indicating that genetic disruption of Acs1 increases fluconazole efficacy and synergy of isoxazole 1 with fluconazole 23 , we further investigated the in vitro toxicity and in vitro pharmacodynamic properties of 1 as a prelude to potential efficacy studies in a mouse model of infection

Cardiorenal Med