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However, most prior studies have examined BCAAs in isolation, without investigating their potential synergistic effects when combined with other functionally complementary amino acids

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found that citrate-covered gold nanoparticles (Cit-AuNP) could prevent the process of NF-B translocation to the nucleus by decreasing the phosphorylation of inhibitor of kappa B alpha (IB), which was followed by decreased expression of pro-inflammatory factor ICAM-1 on leukocytes and reduced adhesion of leukocyte to the endothelium of intracerebral blood vessels, ultimately alleviating the inflammatory response in the brain by BBB protection and reducing the occurrence of SAE during sepsis ( Figure 2 )