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Description

Nature 501 , 5257 (2013)

Collectively, engineered bacteria enhance immunotherapy by targeting three core metabolite-mediated processes in the TME: (1) producing immunostimulatory metabolites (c-di-AMP, L-Arg, butyrate) to activate effector immune cells

Moreover, the affinity of Acs1 for acetate is reported to be several times greater than that of the constitutively expressed Acs2 isoform, suggesting that Acs1 is primarily responsible for acetyl-CoA synthesis during growth on non-fermentable carbon sources such as ethanol 26