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This clustering may be because the coated nanoparticles are repelled by similarly charged hyaluronic acid in the humor, allowing them to move to collagen fibers where hyaluronic acid is absent, says Flix Sauvage, a postdoctoral researcher in De Smedts lab and the first author on the study

Simultaneously, the promoter regions of some inhibitory receptor genes (e.g., PD-1 and TIM-3) present a demethylated state, leading to an upregulation of their expressions by approximately 2-3-fold (158, 159)

The greater neural response in PFC-dependent neural circuits and increased functional connectivity between the dorsolateral PFC and amygdala regions improve symptoms of PTSD during emotional processing (Duval et al., 2020)