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Activation of Sigma-1 receptor alleviates ER-associated cell death and microglia activation in traumatically injured mice

Our results indicate that both serotonin (with EC 50 values of 257 M against RSL3 and 64 M against FINO2) and 5-HIAA (with EC 50 values of 1454 M against RSL3 and 309 M against FINO2) are relatively weak ferroptosis inhibitors compared to the standard inhibitor, Lip-1 (Fig