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Cytokine production after LPS induction was measured with ELISA kits for IL-6 (R&D, M6000B-1) and TNF (BioLegend, 430907)

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At 265 lb, exposure ran 25% to 30% lower. On that class-based model, 1 mg in a 155 lb person can approximate the exposure produced by 1.5 mg in the 240 lb trial cohort