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(5) Song YH, Song JL, Delafontaine P, Godard MP

When combined with Prolotherapy, the localized inflammatory response further promotes healing and the formation of new collagen fibers, enhancing the overall regenerative potential

Finally, because of the emerging role of pericytes in maintaining intra tumour vessels viable, targeting these cells has become the latest approach investigated to overcome resistance to anti VEGF treatment [67,68]

Furthermore, it has been reported that a combination of radiotherapy, chemotherapy, and hyperthermia with Z-VAD-FMK, a necroptosis inducer/pan-caspase inhibitor, can increase macrophage activation, retard tumor growth, and induce immune cell infiltration into tumors through the release of DAMPs in B16 melanoma (66)