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Arthritis Res Ther 25:212

E., Bayindir, Y

The activation of IKK by TRAF6 is achieved through the synthesis of lysine-63 (K63)-linked polyubiquitin chains catalyzed by the ubiquitin ligases Ubc13 and Uev1A, and the TAK1/TAB1/TAB2 protein kinase complex phosphorylates and activates IKK with the assistance of the polyubiquitin chains

Furthermore, emerging evidence suggests that EVs from the oviductal epithelium can act as chemoattractant guides, facilitating the navigation of sperm toward the oocyte, thereby increasing the likelihood of a successful encounter